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Clinical trials
- Participate in a clinical trial
- For medical professionals
- Active clinical trials for pediatric cancers
- CAR-20/19-T cells in pediatric and young adult patients with relapsed/refractory B Cell Acute Lymphoblastic Leukemia (CAR-20/19-T) phase 1 clinical trial
- Unrelated and partially matched related donor peripheral stem cell transplantation for patients with hematologic malignancies clinical trial
- Early stage research
Active clinical trials
Cancer Clinical Trials - NYMC-581
Protocol Summary
- Protocol No
- NYMC-581
- Principal Investigator
- Julie-An Talano
- Phase
- II
- Title
- A Pilot Study in the Treatment of Refractory Epstein-Barr Virus (EBV) Infection with Related Donor EBV Cytotoxic T-Lymphocytes in Children, Adolescents and Young Adult Recipients
- Associated Disease(s)
-
Late Effects and Supportive Studies
- Description (Summary)
- The main purpose of this study is to see if we can safely give special immune cells (Cytotoxic T-cells or CTLs) which have been made from your HSCT donor cells or closely matched family tissue donor and grown in the laboratory. These special immune cells are made to fight your Epstein-Barr Virus.
This study is looking at the safety and effectiveness of the CTLs that can be given to you without causing severe side effects. In this study doctors propose to give you CTLs that have been developed from the blood of your transplant donor or a closely tissue matched family donor. The cells have been cultured against Epstein-Barr Virus that if left untreated could cause death in HSCT patients. Other centers have done similar trials with these types of cells and results have shown that the development process reduces the likelihood that the donor cells could cause graft-versus-host disease (GVHD).
- Participating Institutions
- Childrens Hospital of Wisconsin
- ClinicalTrials.gov
Contact us
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Why participate in clinical trials?
